450.

If you menstruate, that’s about how many periods you’ll have in a lifetime.

Yet even though half the world’s population is menstruating for half their lives…we have very little research on what the hormonal effects actually are…especially in relation to the brain and mental health.

That’s why this new study 👆 is so remarkable.

Neuroscientists tracked 30 women over the course of their menstrual cycles with MRI brain scans and hormone tests—and found brainwide structural changes that correlated with hormone fluctuations 🤯🤯🤯

For example:

🔹 Just before ovulation (when estrogen is high), brains showed changes that indicated faster information transfer.

🔹 The rise of FSH before ovulation was associated with thicker gray matter.

🔹 Progesterone after ovulation correlated with decreased cerebrospinal fluid volume.

What does all this mean?

It means the hormone changes throughout the menstrual cycle influence MORE than just the ovaries and uterus. The more we learn about these hormone-brain connections, the better we can make sense of the domino effect of female hormone balance.

Is your mind blown?

P.S. this study is not yet peer-reviewed but available preprint.

Reference

Rizor EJ, Babenko V, Dundon NM, et al. Menstrual cycle-driven hormone concentrations co-fluctuate with white and grey matter architecture changes across the whole brain bioRxiv 2023. [link & news article]