How to Support Estrogen Metabolism

💥 Not all estrogens are equal.

Maybe you’ve heard that estrogen fuels breast cancer risk.

But did you know that there are many different estrogen metabolites and some present a greater risk than others?

Also, estrogen metabolites interact with genetics, liver enzymes, antioxidants, and other biochemical pathways to ultimately determine breast cancer risk.

Meaning estrogen is only part of the puzzle 🧩

Some things we can do for healthy estrogen metabolism include:

▪️ Support estrogen elimination from the gut with fiber-rich foods, probiotics, and supplements like calcium-d-glucarate

▪️ Support estrogen metabolism in the liver with sulfur-rich foods (like onions, garlic, broccoli, cauliflower, and Brussels sprouts) and antioxidant supplements like resveratrol

▪️ Support production of more favorable estrogen metabolites with supplements like DIM (diindolylmethane) and I3C (indole-3-carbinol)

The best approach is one that is personalized to YOU.

If you are looking to strike the perfect balance of hormonal health today and disease risk reduction down the road, we are here to help.

🌱 Get started at our practice through the link in our bio!

#estrogenmetabolism #breasthealth #hormoneoptimization #hormonehealth

REFERENCES:

-Das S, Somisetty VS, Ulven SM, Matthews J. Resveratrol and 3,3'-Diindolylmethane Differentially Regulate Aryl Hydrocarbon Receptor and Estrogen Receptor Alpha Activity through Multiple Transcriptomic Targets in MCF-7 Human Breast Cancer Cells. Int J Mol Sci. 2023;24(19):14578. [link]

-Siddiqui R, Makhlouf Z, Alharbi AM, Alfahemi H, Khan NA. The Gut Microbiome and Female Health. Biology (Basel). 2022;11(11):1683.. [link]
-Starek-Świechowicz B, Budziszewska B, Starek A. Endogenous estrogens-breast cancer and chemoprevention. Pharmacol Rep. 2021;73(6):1497-1512. [link]

Step 1 = Listen to Your Hormones

But wait! Let me finish ⬇️

Hormonal changes are not the only possible causes for these issues. To fully understand, we need to look at the complete picture, including your health history and labs.

That being said, I believe you deserve to understand your body!

Here’s what more women need to know:

Perimenopause can begin as early as age 35. It’s common for progesterone to decline before estrogen, creating a picture of high estrogen. That means…

👉 Worsening PMS, bloating, and heavy periods rather than what you might be expecting from “menopause.”

The good news is that we have an extensive toolbox to support healthy hormones and ease the transition with lifestyle, nutrition, and supplementation.

📲 Share this with a friend who might want to hear this!

Goitrogenic Foods: Good to Know

How to safely eat goitrogenic foods 👉

You may have heard of “goitrogens,” or foods that interfere with thyroid function. Specifically, these foods interfere with the uptake of iodine into the thyroid gland and the ability of the thyroid to make thyroid hormones.

But when you see a list of goitrogenic foods, you’ll notice that many of these foods are healthy and nutrient-dense foods, like:

🥦 Broccoli, cauliflower, kale, Brussels sprouts, & collards

🥜 Flax seeds, pine nuts, & peanuts

🍠 Millet, corn, & sweet potatoes

🥢 Tofu, tempeh, edamame, & soy milk

While it’s possible for these foods to cause thyroid problems, most people are able to eat moderate amounts without them affecting the thyroid. Here’s what’s good to know:

🔥 Steaming, boiling, or fermenting these foods reduces the goitrogenic effect

🧂 People with an underlying iodine deficiency are at a higher risk of developing thyroid problems when consuming goitrogens

🥦 The biggest risk comes in when these foods are consumed raw and in concentrated amounts (like juices)

Dietary choices always need to be individualized, which is why it is best to work with a knowledgeable practitioner.

🌱 Get started at our practice through the link in our bio!

#goitrogen #thyroidhealingfoods #thyroidhealthyfoods #thyroidnutrition #elementsnatmed

Reference

Petroski W, Minich DM. Is There Such a Thing as "Anti-Nutrients"? A Narrative Review of Perceived Problematic Plant Compounds. Nutrients. 2020;12(10):2929. Published 2020 Sep 24. [link]

It’s Rarely JUST a Thyroid Problem.

Rarely is a thyroid problem JUST a thyroid problem ❌

The thyroid is part of the larger endocrine system—which includes hormones produced in the brain, adrenals, ovaries, and pancreas too.

Here are 3 hormones that influence (and are influenced by) the thyroid:

🍭 Insulin

Both overactive and underactive thyroid can disrupt glucose metabolism and contribute to insulin resistance. The reverse is also true, with insulin resistance being associated with conversion of T4 to reverse T3 (inactive thyroid hormone) rather than active T3.

😩 Cortisol

Underactive thyroid contributes to higher cortisol levels (a stress hormone) because of reduced cortisol clearance. Also, high levels of cortisol are associated with reduced T4 production and higher levels of reverse T3 (inactive thyroid hormone).

🌸 Estrogen

The hormone cascades connecting the brain to the thyroid and the brain to the ovaries work together. Both overactive and underactive thyroid can disrupt the menstrual cycle and irregular periods or fertility challenges.

It’s because of these connections that it’s so important to take a holistic approach when optimizing thyroid function.

Like ❤️ if you learned something and follow 🚶‍♀️ for upcoming posts on how to optimize your thyroid function!

References

Gierach M, Gierach J, Junik R. Insulin resistance and thyroid disorders. Endokrynol Pol. 2014;65(1):70-76. [link]

Saei Ghare Naz M, Rostami Dovom M, Ramezani Tehrani F. The Menstrual Disturbances in Endocrine Disorders: A Narrative Review. Int J Endocrinol Metab. 2020;18(4):e106694. [link]

Sinha SR, Prakash P, Keshari JR, Kumari R, Prakash V. Assessment of Serum Cortisol Levels in Hypothyroidism Patients: A Cross-Sectional Study. Cureus. 2023;15(12):e50199. [link]

The Thyroid Triad (Gut & Liver!)

Want better thyroid function? 👉

Then we also need to optimize the liver and the gut. Here’s why:

🔁 Thyroid & Gut:

Thyroid hormones influence gut motility (causing constipation when underactive). Gut dysbiosis or inflammation can worsen oxidative stress that damages the thyroid.

🔁 Thyroid & Liver:

Thyroid hormones influence fat metabolism in the liver (contributing to insulin resistance and fatty liver when underactive). Conversion of T4 to active T3 takes place in the liver, meaning that a compromised liver could compromise thyroid function.

Poor thyroid function can impair gut and liver function—and the reverse is also true.

If you struggle with thyroid health and want to take a holistic approach to feeling better, we can help.

🌱 Get started at our practice through the link in our bio!

Reference

Hatziagelaki E, Paschou SA, Schön M, Psaltopoulou T, Roden M. NAFLD and thyroid function: pathophysiological and therapeutic considerations. Trends Endocrinol Metab. 2022;33(11):755-768. [link]

Knezevic J, Starchl C, Tmava Berisha A, Amrein K. Thyroid-Gut-Axis: How Does the Microbiota Influence Thyroid Function?. Nutrients. 2020;12(6):1769. Published 2020 Jun 12. [link]